Sheng-Yu Lee Selected Research

Dextromethorphan (Racemethorphan)

2/2020	Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder.
2/2017	The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder.
10/2015	ALDH2 polymorphism, associated with attenuating negative symptoms in patients with schizophrenia treated with add-on dextromethorphan.
11/2014	Therapeutic effects of add-on low-dose dextromethorphan plus valproic acid in bipolar disorder.
12/2012	Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment.
9/2012	Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan.
5/2012	The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder.

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Sheng-Yu Lee Research Topics

Disease

30	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 02/2022 - 08/2014
23	Bipolar Disorder (Manic Depressive Psychosis) 02/2020 - 08/2009
10	Inflammation (Inflammations) 09/2021 - 09/2012
9	Opioid-Related Disorders (Opiate Addiction) 01/2021 - 12/2012
8	Schizophrenia (Dementia Praecox) 06/2019 - 09/2012
8	Alcoholism (Alcohol Abuse) 01/2018 - 06/2009
6	Antisocial Personality Disorder (Antisocial Personality) 09/2021 - 06/2009
5	Cognitive Dysfunction 01/2019 - 01/2012
5	Mania (Manias) 01/2018 - 11/2014
4	Major Depressive Disorder (Major Depressive Disorders) 01/2022 - 12/2008
4	Depressive Disorder (Melancholia) 12/2020 - 07/2010
4	Anxiety Disorders (Anxiety Disorder) 01/2018 - 01/2013
4	Heroin Dependence (Heroin Abuse) 10/2017 - 01/2012
3	Substance-Related Disorders (Drug Abuse) 02/2020 - 12/2012
2	Neuroinflammatory Diseases 01/2021 - 11/2017
2	Mood Disorders (Mood Disorder) 02/2020 - 01/2017
2	Psychotic Disorders (Schizoaffective Disorder) 01/2020 - 10/2015
2	Neurodevelopmental Disorders 10/2018 - 01/2018
2	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 05/2015
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 08/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2016 - 02/2015
2	Necrosis 01/2016 - 01/2016
1	Tobacco Use Disorder (Nicotine Dependence) 11/2021

Drug/Important Bio-Agent (IBA)

16	Brain-Derived Neurotrophic Factor (BDNF)IBA 09/2021 - 11/2010
12	Methylphenidate (Ritalin)FDA LinkGeneric 01/2022 - 08/2014
12	CytokinesIBA 01/2022 - 09/2012
11	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2016
9	Pharmaceutical PreparationsIBA 01/2022 - 01/2013
8	Memantine (Namenda)FDA Link 01/2021 - 08/2012
7	Methadone (Dolophine)FDA LinkGeneric 01/2021 - 12/2012
7	Aldehyde DehydrogenaseIBA 02/2020 - 01/2012
7	Valproic Acid (Depakote)FDA LinkGeneric 02/2020 - 05/2012
7	Dextromethorphan (Racemethorphan)FDA LinkGeneric 02/2020 - 05/2012
6	Testosterone (Sustanon)FDA Link 01/2021 - 01/2017
6	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 06/2009
5	Biological ProductsIBA 01/2022 - 01/2016
5	Antipsychotic Agents (Antipsychotics)IBA 06/2019 - 02/2015
4	Hormones (Hormone)IBA 02/2022 - 01/2019
4	Dehydroepiandrosterone (DHEA)IBA 01/2019 - 08/2014
4	4-aminospiroperidolIBA 11/2017 - 06/2009
4	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 03/2016 - 01/2016
3	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2018
3	Antidepressive Agents (Antidepressants)IBA 01/2022 - 11/2010
3	Gonadal HormonesIBA 01/2021 - 01/2019
3	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 01/2021 - 05/2015
3	Delayed-Action PreparationsIBA 01/2020 - 01/2016
3	Nerve Growth Factors (Neurotrophins)IBA 11/2019 - 08/2012
3	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2019 - 01/2017
3	C-Reactive ProteinIBA 10/2017 - 01/2012
3	Risperidone (Risperdal Consta)FDA LinkGeneric 01/2016 - 09/2012
3	Serotonin (5 Hydroxytryptamine)IBA 08/2012 - 06/2009
3	Serotonin ReceptorsIBA 08/2012 - 09/2009
2	Endocrine DisruptorsIBA 02/2022 - 08/2020
2	Growth Hormone (Somatotropin)IBA 02/2022 - 01/2022
2	Insulin-Like Growth Factor I (IGF-1)IBA 02/2022 - 01/2022
2	mono-(2-ethylhexyl)phthalateIBA 02/2022 - 08/2020
2	Fluoxetine (Prozac)FDA LinkGeneric 01/2022 - 01/2016
2	Progesterone FDA LinkGeneric 01/2021 - 08/2020
2	Cystine (L-Cystine)IBA 01/2021 - 01/2021
2	Therapeutic UsesIBA 01/2021 - 11/2014
2	Neuroprotective AgentsIBA 01/2021 - 08/2012
2	Proteins (Proteins, Gene)FDA Link 11/2019 - 01/2018
2	N 30IBA 01/2018 - 08/2009
2	Interleukin-8 (Interleukin 8)IBA 01/2018 - 01/2016
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2018 - 08/2014
2	LipidsIBA 10/2017 - 12/2012
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 02/2017 - 06/2014
2	NeurosteroidsIBA 01/2017 - 08/2014
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016 - 01/2016
2	Indicators and Reagents (Reagents)IBA 01/2016 - 10/2015
2	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 06/2015 - 03/2015
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 02/2014 - 07/2012
2	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 02/2014 - 07/2012
2	Heroin (Diamorphine)IBA 06/2013 - 12/2012
2	Monoamine Oxidase (MAO)IBA 01/2013 - 06/2009
2	aldehyde dehydrogenase (NAD(P)+) (acetaldehyde dehydrogenase)IBA 09/2012 - 06/2009
2	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 07/2010 - 09/2009
1	Insulin-Like Growth Factor Binding Protein 3IBA 02/2022
1	Thyroid HormonesIBA 01/2022
1	GABA-A Receptors (GABA(A) Receptor)IBA 11/2021
1	Proteoglycans (Proteoglycan)IBA 11/2021
1	CalciumIBA 11/2021
1	HydroxylysineIBA 01/2021
1	phosphorylethanolamine (phosphoethanolamine)IBA 01/2021
1	IsotopesIBA 01/2021
1	AcidsIBA 01/2021
1	HypoxanthineIBA 01/2021
1	p-Aminohippuric Acid (p-Aminohippurate)FDA Link 01/2021
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2021
1	Leucine (L-Leucine)FDA Link 01/2021
1	Fenofibrate (CiL)FDA LinkGeneric 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2021
1	GuanosineIBA 01/2021
1	2,5-dihydroxybenzoic acid (gentisic acid)IBA 01/2021
1	Estradiol (Delestrogen)FDA LinkGeneric 08/2020
1	bisphenol AIBA 08/2020
1	ParabensIBA 08/2020

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 01/2022 - 01/2016
7	Therapeutics 01/2021 - 08/2012
1	Transcranial Magnetic Stimulation 01/2021